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              服務熱線

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              hPDL-1/mPDL-1null

              1. 基本信息

              品系名稱:B6-Tg(CAG- hPDL-1)5Vst mPDL-1em1Vst/Vst

              常用名mPDL-1null PD-1人源化小鼠; hPD-1/mPDL-1null小鼠

              背景C57BL/6NCrl

              毛色黑色


              品系建立

              采用轉基因的方法,構建CAG- hPDL-1表達載體,酶切分離表達載體片段,將該片段注射到C57BL/6NCrl小鼠的原核中。在后代中篩選到合適表達量的陽性小鼠,與mPD-L1null小鼠交配,獲得同時敲除mPDL-1和過表達hPDL-1的小鼠。


              2. 應用領域

              -人源化和癌癥治療

              -免疫治療

              -藥物篩選


              3. 參考文獻

              (1)Association of PD-L1 expression and PD-L1 gene polymorphism with poor prognosis in lung adenocarcinoma and squamous cell carcinoma.Yeo MK, Choi SY, Seong IO, Suh KS, Kim JM, Kim KH.Hum Pathol. 2017 Oct; 68: 103-111. doi: 10.1016/j.humpath.2017.08.016. Epub 2017 Aug 26.

              (2)Gene code CD274/PD-L1: from molecular basis toward cancer immunotherapy.Fabrizio FP, Trombetta D, Rossi A, Sparaneo A, Castellana S, Muscarella LA.Ther Adv Med Oncol. 2018 Dec 17;10:1758835918815598. doi: 10.1177/1758835918815598. eCollection 2018.


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